Injection treatment for Peyronie’s Disease

Advanced Urological Procedures

Injection Treatment For Peyronie’s Disease

How does XIAFLEX® work?

XIAFLEX® helps disrupt 2 collagen types within a Peyronie's plaque1

At higher doses and longer incubation times, nonfibrillar type IV collagen was affected causing collagen lysis in small veins1
Did not cause structural damage to arteries, nerves, or large veins that contain type IV collagen in in vitro or in vivo studies1
There are no clinical data regarding the relative contributions of the individual collagenases to the efficacy of XIAFLEX® in the treatment of Peyronie’s disease1

Injection of XIAFLEX® into collagen-containing structures such as the corpora cavernosa of the penis may result in damage to those structures and possible injury such as corporal rupture (penile fracture). Therefore, XIAFLEX® should be injected only into the Peyronie’s plaque and care should be taken to avoid injecting into the urethra, nerves, blood vessels, corpora cavernosa, or other collagen-containing structures of the penis.1

AUA Peyronie's Disease Treatment Guideline For XIAFLEX®

In 2015, the American Urological Association (AUA) published a guideline that provides a clinical framework for the diagnosis and treatment of Peyronie's disease. The following guideline statements are specific to XIAFLEX®.

Clinicians may administer intralesional collagenase clostridium histolyticum in combination with modeling by the clinician and by the patient for the reduction of penile curvature in patients with stable Peyronie's disease, penile curvature >30° and <90°, and intact erectile function (with or without the use of medications). (Moderate Recommendation; Evidence Strength Grade B)2
Clinicians should counsel patients with Peyronie's disease prior to beginning treatment with intralesional collagenase regarding potential occurrence of adverse events, including penile ecchymosis, swelling, pain, and corporal rupture. (Clinical Principle)2
Moderate Recommendations are directive statements that an action should (benefits outweigh risks/burdens) or should not (risks/burdens outweigh benefits) be undertaken because net benefit or net harm is moderate2
Body of Evidence Strength Grade B in support of a Moderate Recommendation indicates that the statement can be applied to most patients in most circumstances but that better evidence could change confidence2

A Clinical Principle is a statement about a component of clinical care that is widely agreed upon by urologists or other clinicians for which there may or may not be evidence in the medical literature.2

What Does Treatment With XIAFLEX® Consist Of?

A treatment course of XIAFLEX® takes ~24 weeks and consists of up to 4 treatment cycles approximately 6 weeks apart1.

If the curvature deformity is less than 15 degrees after the first, second, or third treatment cycle, or if further treatment is not clinically indicated, then subsequent treatment cycles should not be administered.1

The safety of more than one treatment course of XIAFLEX® is not known.1

Each Treatment Cycle Involves1:

3 office visits over the course of 3–7 days
Each cycle begins with the injection of XIAFLEX® into the palpable Peyronie's plaque
The second injection is performed 1–3 days later after the first injection Based on patient's penile swelling, you can assess if he is ready for the second injection
In-office modeling is performed 1–3 days after the second injection
The patient then performs at-home daily penile modeling for approximately 6 weeks

Office Locations

Corona Office

Riverside Office

Murrieta Office

The Urology Center of Southern California is a single-specialty urology group which was founded in 1985.

Advanced Urological Procedures